The Juan B. Castagnino Fine Arts Museum (Spanish: Museo de Bellas Artes Juan B. Castagnino) is an art museum in the city of Rosario, province of Santa Fe, Argentina, considered the most important of the interior of the country and the second in national terms. It is administered by the municipal government. The museum lies within the Parque de la Independencia (the largest of Rosario's urban parks) immediately outside the city center, at the intersection of Oroño Boulevard and Pellegrini Avenue.